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KMID : 0043319920150040336
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Archives of Pharmacal Research
1992 Volume.15 No. 4 p.336 ~ p.342
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Synthesis of Some Palladium(II) Complexes of 1,2-Diaminocyclohexane and Dicarboxylates as Cisplatin knalogues of Palladium Series
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Kim JY
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Abstract
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Ten[PdII(dicarboxylato)(1,2-diaminocyclohexane)] complexes were prepered after the antitumor-active Pt(II)-1,2-diaminocyclohexane complexes as the cisplatin analogues of palladium series. They were chracterized by means of elemental anaylysis, IR and NMR spectroscopy. As a result, the dicarboxylate ligands were confirmed to be chelated with Pd(II) within the scope studied. The stability differences between the dicarboxylato complexes according to the chelate ring size could not be differentiated due to generally lower thermodynamic stability of the dicarboxylato Pd(II) complexes.
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